Optimization of ultrasonic-assisted extraction (UAE) of phenolics and antioxidant compounds from rhizomes of Rheum moorcroftianum using response surface methodology (RSM)

Abstract This study for the first time designed to optimize the extraction of polyphenolic compounds from rhizomes of Rheum moorcroftianum using response surface methodology (RSM). Solvent was selected based on the preliminary experiments, and a four-factors-three-level, Box–Behnken Design (BBD) including 29 experimental runs. The polyphenolic content and antioxidant activity was significantly (p