衰老
听力损失
听力学
老年性聋
听觉脑干反应
脑干
人口
医学
耳蜗
神经科学
心理学
内科学
环境卫生
作者
Aurore Marie,Philippe Larroze-Chicot,Sylvie Cosnier-Pucheu,Sergio González-González
标识
DOI:10.1016/j.neulet.2017.07.037
摘要
Hearing loss is the most common form of sensory impairment in humans, affecting 5.3% worldwide population. In industrial countries, age-related hearing loss is a major health problem affecting one-third of individuals over 65 years old. However, the physiological and molecular changes involved in this senescence process remain unclear. In this study, we determined the influence of age on auditory brainstem response (ABR) and the distortion product otoacoustic emissions (DPOAE) in the premature senescence mouse model SAMP8 for five months. We showed a progressive increase of ABR thresholds and a decrease of distortion product amplitude from 37 days old in SAMP8 compared to CBA mice. The data we show here provide new knowledge in functional auditory changes during the senescence process and open up new opportunities for the development of new drugs involved in age-related hearing loss treatment.
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