纳米点
光热治疗
材料科学
纳米笼
光动力疗法
体内
纳米技术
纳米材料
牛血清白蛋白
生物医学工程
化学
医学
色谱法
生物技术
有机化学
催化作用
生物
生物化学
作者
Qiutong Jin,Jingjing Liu,Wenjun Zhu,Ziliang Dong,Zhuang Liu,Liang Cheng
标识
DOI:10.1021/acsami.7b16890
摘要
Current mainstream cancer treatment methods have their limitations. New approaches are thus desired to assist our battle against cancer. Herein, multifunctional ultrasmall FeS2 nanodots with the size of 7 nm are synthesized by biomineralization and used for imaging-guided combined tumor therapy. Bovine serum albumin (BSA), which acts as the reaction template to induce the mineralization of FeS2 nanomaterials under alkaline conditions, could also be used as a drug delivery system for coupling photosensitive molecule such as Chlorin e6 (Ce6). Taking advantage of the near-infrared (NIR) absorbance and the high r2 relaxivity of the synthesized ultrasmall FeS2 nanodots, as well as the Ce6 fluorescence, in vivo trimodal imaging of optical/magnetic resonance/photoacoustics was carried out, showing efficient tumor accumulation of FeS2@BSA-Ce6 after intravenous injection. In vitro and in vivo photothermal and photodynamic therapy were then conducted for synergistic tumor therapy and did not cause any apparent toxicity to the treated animals. Our work thus provides a new kind of ultrasmall FeS2 multifunctional nanodot modified by albumin via a simple method, promising for combination phototherapy as well as cancer theranostics.
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