肝纤维化
阿佩林
肾
医学
纤维化
受体
机制(生物学)
肾素-血管紧张素系统
心脏纤维化
血管紧张素II
癌症研究
细胞生物学
内科学
血压
作者
Yu Zhang,Pei Ting Luo,Xin Yang Li,Wen Peng Cui
出处
期刊:Acta Academiae Medicinae Sinicae
日期:2021-04-28
卷期号:43 (2): 278-282
标识
DOI:10.3881/j.issn.1000-503x.13014
摘要
Elabela is a newly discovered peptide in recent years.It is the endogenous ligand of Apelin receptor(APJ)and plays an important role in embryonic development and adult organs.Elabela-APJ axis is closely related to organ fibrosis.Elabela can protect the functions of heart and kidney by antagonizing renin-angiotensin system and regulating blood pressure.In addition,it can prevent kidney and heart fibrosis by down-regulating the expression of fibrosis and inflammatory factors.However,there is a positive correlation between the level of Elabela and the degree of liver fibrosis,suggesting that Elabela may play a role in promoting liver fibrosis.This review aims to explore the role of Elabela-APJ axis in renal fibrosis,cardiac fibrosis,and liver fibrosis,and to provide a new therapeutic target for organ fibrosis.
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