脂质代谢
生物
脂肪酸合酶
转移
癌症研究
脂肪生成
PI3K/AKT/mTOR通路
肿瘤微环境
信号转导
癌症
脂肪酸
细胞生物学
脂肪酸代谢
生物化学
肿瘤细胞
遗传学
作者
Jingyue Zhang,Yawen Song,Qianqian Shi,Li Fu
标识
DOI:10.1007/s11684-021-0830-0
摘要
Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism, which is manifested by increased endogenous fat mobilization, hypertriglyceridemia, and increased fatty acid synthesis. Fatty acid synthase (FASN) is a key enzyme for the de novo synthesis of fatty acids, and monoacylglycerol esterase (MGLL) is an important metabolic enzyme that converts triglycerides into free fatty acids. Both enzymes play an important role in lipid metabolism and are associated with tumor-related signaling pathways, the most common of which is the PI3K-AKT signaling pathway. They can also regulate the immune microenvironment, participate in epithelial-mesenchymal transition, and then regulate tumor invasion and metastasis. Current literature have shown that these two genes are abnormally expressed in many types of tumors and are highly correlated with tumor migration and invasion. This article introduces the structures and functions of FASN and MGLL, their relationship with abnormal lipid metabolism, and the mechanism of the regulation of tumor invasion and metastasis and reviews the research progress of the relationship of FASN and MGLL with tumor invasion and metastasis.
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