医学
左旋甲状腺素
先天性甲状腺功能减退
碘
甲状腺球蛋白
新生儿筛查
碘缺乏症
肌酐
内科学
儿科
泌尿系统
尿
甲状腺
胃肠病学
内分泌学
泌尿科
材料科学
冶金
作者
Makiko Tachibana,Yoko Miyoshi,Miho Fukui,Shinsuke Onuma,Tetsuo Fukuoka,Yutaka Satomura,Kie Yasuda,Takeshi Kimura,Kazuhiko Bessho,Keiichi Ozono
标识
DOI:10.1515/jpem-2021-0205
摘要
Iodine deficiency and excess both cause thyroid dysfunction. Few data describe the relationship between iodine status and outcomes of congenital hypothyroidism (CH) in iodine-sufficient areas. We investigated urinary iodine (UI) concentration and its relationship with the clinical course of CH.We reviewed and retrospectively analyzed patients with positive newborn screening (NBS) for CH from January 2012 to June 2019 in Japan, obtaining UI and UI-urine creatinine ratio (UI/Cr), serum TSH, free T4, free T3 and thyroglobulin (Tg) at the first visit, TSH at NBS, levothyroxine (LT4) dose, and subsequent doses. A UI value of 100-299 μg/L was considered adequate.Forty-eight patients were included. Median UI and UI/Cr were 325 μg/L and 3,930 µg/gCr, respectively. UI was high (≥300 μg/L) in 26 (54%) and low (≤99 μg/L) in 11 (23%). LT4 was administered to 34 patients. Iodine status was not related to the need for treatment. We found a U-shaped relationship between Tg and UI/Cr. Patients with high Tg (≥400 ng/mL) and abnormal UI levels required significantly lower LT4 doses (≤20 µg/day) at three years of age. Even if they showed severe hypothyroidism initially, they did not need subsequent dose increments.Abnormal UI levels with Tg elevation were associated with lower LT4 dose requirements. The evaluation of iodine status and Tg concentrations were considered useful in patients suspected of CH.
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