Super-Enhancer–Driven HCG20 Promotes Pulmonary Hypertension Through U2AF2 Splicing

Collectively, our data suggest that HCG20, driven by SE, contributes to PAEC dysfunction through U2AF2-mediated alternative splicing of EIF2AK2. Our work underscores the potential of using HCG20 as a novel biomarker and a promising target for the treatment of PH.