Sacrificial gelatin of PAM-Alginate-BC hydrogel tube with tunable diameter as nerve conduit

Peripheral nerve regeneration is still one of the biggest challenges, autologous nerve transplantation is the 'gold standard' for evaluating its alternative therapy. However, the source of autologous nerves is limited, it is imminent to synthesize a nerve-guiding catheter material with a controllable diameter of a small orifice. Sacrificial gelatin polyacrylamide-Alginate-Bacterial cellulose (PAM-Alginate-BC) hydrogel overcomes poor mechanical properties with tunable diameter. In addition, the PAM-Alginate-BC hydrogel possesses the beneficial properties required for cell scaffolding with surface adhesion ability. The PAM-Alginate-BC materials options have potential applications in peripheral nerve regeneration.