骨骼肌
肌肉肥大
肌萎缩
心肌细胞
细胞生物学
肌生成抑制素
去神经支配
肌肉萎缩
信号转导
生物
萎缩
内分泌学
内科学
医学
作者
Anirban Roy,Vihang A. Narkar,Ashok Kumar
出处
期刊:BioEssays
[Wiley]
日期:2023-02-15
卷期号:45 (4)
标识
DOI:10.1002/bies.202300003
摘要
Maintenance of skeletal muscle mass and strength throughout life is crucial for heathy living and longevity. Several signaling pathways have been implicated in the regulation of skeletal muscle mass in adults. TGF-β-activated kinase 1 (TAK1) is a key protein, which coordinates the activation of multiple signaling pathways. Recently, it was discovered that TAK1 is essential for the maintenance of skeletal muscle mass and myofiber hypertrophy following mechanical overload. Forced activation of TAK1 in skeletal muscle causes hypertrophy and attenuates denervation-induced muscle atrophy. TAK1-mediated signaling in skeletal muscle promotes protein synthesis, redox homeostasis, mitochondrial health, and integrity of neuromuscular junctions. In this article, we have reviewed the role and potential mechanisms through which TAK1 regulates skeletal muscle mass and growth. We have also proposed future areas of research that could be instrumental in exploring TAK1 as therapeutic target for improving muscle mass in various catabolic conditions and diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI