Bimetallic nanoplatform for synergistic sonodynamic-calcium overload therapy utilizing self-supplied hydrogen peroxide and relieved hypoxia

This study introduces a bimetallic nanoplatform (Fe 3 O 4 -TAPP@PVP-CaO 2 ) that addresses the limitations in sonodynamic therapy. It enhances oxygen supply, generates toxic reactive oxygen species, and triggers cancer cell death through calcium overload.