PHARMACOKINETIC AND PHARMACODYNAMIC ALTERATIONS OF LOCAL ANESTHETICS IN PATIENTS WITH SYSTEMIC DISORDERS: A NARRATIVE REVIEW.
作者
З. С. Хабадзе,E Starodubtseva,D Pervozvanova,A. N. Vavilova,P Pogodina,Virginia J. Savin,N. A. Dolzhikov,G. G. Avetisian,D. F. Rasulova,D. D. Khubulova,Erdinç Aydın
出处
期刊：PubMed [National Institutes of Health] 日期：2025-10-01卷期号： (367): 65-72
Since systemic diseases can significantly modify the bioavailability, metabolism, and pharmacokinetics of local anesthetics, anesthetic protocols should be individualized for each patient based on their specific comorbid condition and metabolic status.
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(2025-6-4)
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