Infertility is an increasingly prevalent global health issue affecting millions of couples. It can arise from various factors, including hormonal imbalances, reproductive disorders, and anatomical abnormalities. While numerous treatment options exist, such as assisted reproductive technologies, these approaches often entail significant costs and have limited success rates. In this paper, we review the role of mesenchymal stem cell exosomes (MSC-Exos) in the treatment of infertility, with a particular focus on their potential to enhance fertility. We herein aimed to integrate the latest research progress in this field and emphasize the importance of MSC-Exos as a potential treatment for infertility.