冠状动脉疾病
医学
小RNA
计算机辅助设计
血管生成
发病机制
疾病
生物信息学
生物标志物
诊断生物标志物
长非编码RNA
癌症研究
内科学
基因
下调和上调
癌症
生物
遗传学
生物化学
作者
Yong Jiang,Ying Zhao,Zhengyi Li,Shuang Chen,Fang Fang,Jianhui Cai
标识
DOI:10.1016/j.ijcard.2023.03.067
摘要
Coronary artery disease (CAD), which is mainly caused by atherosclerotic processes in coronary arteries, became a significant health issue. MicroRNAs (miRNAs), and long noncoding RNAs (lncRNAs), have been shown to be stable in plasma and could thereby be adopted as biomarkers for CAD diagnosis and treatment. MiRNAs can regulate CAD development through different pathways and mechanisms, including modulation of vascular smooth muscle cell (VSMC) activity, inflammatory responses, myocardial injury, angiogenesis, and leukocyte adhesion. Similarly, previous studies have indicated that the causal effects of lncRNAs in CAD pathogenesis and their utility in CAD diagnosis and treatment, has been found to lead to cell cycle transition, proliferation dysregulation, and migration in favour of CAD development. Differential expression of miRNAs and lncRNAs in CAD patients has been identified and served as diagnostic, prognostic and therapeutic biomarkers for the assessment of CAD patients. Thus, in the current review, we summarize the functions of miRNAs and lncRNAs, which aimed to identify novel targets for the CAD diagnosis, prognosis, and treatment.
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