材料科学
生物医学工程
间质液
可穿戴计算机
血液取样
采样(信号处理)
持续监测
纳米技术
计算机科学
嵌入式系统
医学
运营管理
计算机视觉
滤波器(信号处理)
内科学
经济
作者
Taher Abbasiasl,Fariborz Mirlou,Hadi Mirzajani,Mohammad Javad Bathaei,Emin Istif,Narges Shomalizadeh,Rümeysa Emine Cebecioğlu,Ecem Ezgi Özkahraman,Umut Can Yener,Levent Beker
标识
DOI:10.1002/adma.202304704
摘要
Abstract Dermal interstitial fluid (ISF) is emerging as a rich source of biomarkers that complements conventional biofluids such as blood and urine. However, the impact of ISF sampling in clinical applications has been limited owing to the challenges associated with extraction. The implementation of microneedle‐based wearable devices that can extract dermal ISF in a pain‐free and easy‐to‐use manner has attracted growing attention in recent years. Here, a fully integrated touch‐activated wearable device based on a laser‐drilled hollow microneedle (HMN) patch for continuous sampling and sensing of dermal ISF is introduced. The developed platform can produce and maintain the required vacuum pressure (as low as ≈ −53 kPa) to collect adequate volumes of ISF (≈2 µL needle −1 h −1 ) for medical applications. The vacuum system can be activated through a one‐touch finger operation. A parametric study is performed to investigate the effect of microneedle array size, vacuum pressure, and extraction duration on collected ISF. The capability of the proposed platform for continuous health monitoring is further demonstrated by the electrochemical detection of glucose and pH levels of ISF in animal models. This HMN‐based system provides an alternative tool to the existing invasive techniques for ISF collection and sensing for medical diagnosis and treatment.
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