细菌纤维素
伤口愈合
聚己内酯
明胶
纳米纤维
生物医学工程
渗透(战争)
自愈水凝胶
材料科学
体内
纤维素
伤口敷料
药物输送
伤口护理
复合材料
化学工程
化学
医学
外科
纳米技术
高分子化学
聚合物
生物化学
生物技术
运筹学
工程类
生物
作者
Homa Mohaghegh,Zahra Assadi,Amin Derakhshan,Elahe Masaeli
标识
DOI:10.1016/j.xphs.2023.09.018
摘要
Materials that speed up wound healing can be of great benefit to patients and healthcare providers. One-layer dressings, however, have unsatisfactory healing efficacy since it is impossible to use materials with different properties simultaneously, and drug delivery is limited by the depth of penetration. The present study utilized a multilayer wound dressing composed of bacterial cellulose (BC) hydrogel, gelatin/alginate (Gel/Alg) hydrogel, and polycaprolactone (PCL) nanofibers loaded with ciprofloxacin (CIP) to promote the healing process in vivo. The designed dressings showed significant water absorption and sufficient water vapor transmission rate (WVTR) after one week, confirming their ability to absorb wound exudate. Within the first four hours, significant amounts of CIP were released from the drug-containing dressing. Then, between hours 4 and 24, the rate decreased and plateaued on day 9. Both positive and negative bacterial strains were inhibited by the gradual release of CIP, while fibroblasts retained their normal morphology and metabolic activity. Lastly, in vivo tests demonstrated that CIP-loaded multilayer dressings could significantly speed up full-thickness wound healing during 14 days, by reducing inflammation, stimulating re-epithelialization, and enhancing skin regeneration. Our findings indicate that multilayering BC hydrogels with drug-loaded nanofibers provide a promising way to promote wound healing by utilizing all the distinctive properties of these layers.
科研通智能强力驱动
Strongly Powered by AbleSci AI