细胞代谢
控制(管理)
可持续生产
计算机科学
控制逻辑
透视图(图形)
生化工程
生产(经济)
生物
工程类
新陈代谢
人工智能
经济
生物化学
宏观经济学
计算机硬件
作者
Tao Jiang,Chenyi Li,Yuxi Teng,Jianli Zhang,D.P. Logan,Yajun Yan
标识
DOI:10.35534/sbe.2023.10012
摘要
Establishing microbial cell factories has become a sustainable and increasingly promising approach for the synthesis of valuable chemicals. However, introducing heterologous pathways into these cell factories can disrupt the endogenous cellular metabolism, leading to suboptimal production performance. To address this challenge, dynamic pathway regulation has been developed and proven effective in improving microbial biosynthesis. In this review, we summarized typical dynamic regulation strategies based on their control logic. The applicable scenarios for each control logic were highlighted and perspectives for future research direction in this area were discussed.
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