肿瘤微环境
IDH1
免疫系统
突变体
异柠檬酸脱氢酶
髓样
趋化因子
癌症研究
体内
肿瘤坏死因子α
免疫疗法
生物
免疫学
基因
生物化学
生物技术
酶
作者
Daniel J. Zabransky,Emma Kartalia,Jae W. Lee,James M. Leatherman,Soren Charmsaz,Sara E. Young,Yash Chhabra,Sebastià Franch‐Expósito,Martin Kang,Saumya Maru,Noushin Rastkari,Michael S. Davis,W. Brian Dalton,Kiyoko Oshima,Marina Baretti,Nilofer S. Azad,Elizabeth M. Jaffee,Mark Yarchoan
出处
期刊：Hepatology
[Lippincott Williams & Wilkins]
日期：2024-12-03
卷期号：82 (3): 599-611
被引量：7
标识
DOI：10.1097/hep.0000000000001185
摘要
IDH1- mutant CCA is characterized by an increased abundance of M2-like TAMs. Targeting CCL2 remodels the tumor immune microenvironment and improves outcomes in preclinical models of IDH1 -mutant CCA, highlighting the role of myeloid-targeted immunotherapies in the treatment of this cancer.
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