Advances research in chromatin DNaseI hypersensitive sites and its transcriptional regulation function

DNaseⅠ hypersensitive sites( DHSs) are regions of extreme chromatin which is highly sensitive to DNaseⅠ. Genome-wide mapping DHSs is a powerful method for identifying many different types of regulatory elements within nuclear chromatin. It can help systematically resolve gene and genomic information,and the dynamic molecular mechanism of transcriptional regulation. This paper reviews the distribution of DHSs,the technology of DNase-seq and the research progress in transcriptional regulation functions of DHSs.