Objective To investigate the indications and therapeutic effects of pancreaticoduodenectomy in patients more than 70 years old with periampullary cancer.Methods A retrospective analysis of 27 consecutive patients more than 70 years old who had underwent pancreaticoduodenectomies from Jan 1995 to June 2002 was made.Results Postoperative complications occurred in 12 patients(44.4%),including 3 cases of intraabdominal bleedings,2 gastrointestinal bleedings,3 pancreatic leakages,4 gastroparalysis and 3 wound infections.Three patients(11.1%) died within 30 days postoperatively.The average survival time was 15.3 months except for 8 patients who are still alive 18 months aften operation.Four patients survived more than 3 years with 3-year survival rate of 21.0%(4/19).Conclusion Old people is not a contraindication of pancreaticoduodenectomy.Pancreaticoduodenectomy is an effective method for patients more than 70 years of age with periampullary cancer.