The correlations between the fault system and the overpressure fluid activity have been studied based on an integrated analysis of faults, overpressure fluids and their geodynamic evolution in Yinggehai basin. Furthermore, their constrained relationship has been proposed. Faults first induced episodic explosion of overpressure fluids, overpressure fluid activity deduced chiefly faults or fractures, including hydrologic fractures, in overlying strata in succession, and then overpressure was released along these faults and fractures. Meanwhile, overpressure fluid activity opened new faults or promoted previous faults, which would serve as predisposition for further overpressure fluid explosion.