Camparison of bioavailability between the sustained release Indometacin capsule and a commercially available capsule in human

The in vitro dissolution rates and the comparison of a cross-over bio-availability in 8 adult health volunteers between the sustained release indometacin capsule and a commercially available capsule were examined. The serum samples were assayed for indometacin by HPLC. The in vitro dissolution behaviour of the two capsule formulations exhibited a significant difference. The in vivo bioavaila-bility of different capsule formulations, although their absorped degree(AUC ,_14 h) were almost the same, Cmax and Tmax of the sustained release capsule were significantly lower and latter than that of the commercially available capsule (P 0.01).The sustained release capsule demonstrated a higher and smooth concentration-time curves than that of the commercially available capsule from 4-12 k following a single dose(50 mg) of indorriete.cin, and their serum level were significantly higher than that of the latter(P0.05).The results suggest that the sustained release indometacin capsule can avoid high initial peak of the commercially available capsule arid increase the interval between dosage.