螺旋藻(膳食补充剂)
结肠炎
硒
炎症性肠病
炎症
免疫系统
化学
藻蓝蛋白
肿瘤坏死因子α
促炎细胞因子
免疫学
内科学
医学
生物
疾病
蓝藻
原材料
细菌
有机化学
遗传学
作者
Chenghui Zhu,Qinjie Ling,Zhihui Cai,Yun Wang,Yibo Zhang,Peter Hoffmann,Wenjie Zheng,Tianhong Zhou,Zhi Huang
标识
DOI:10.1021/acs.jafc.6b01308
摘要
Selenium (Se) plays an important role in fine-tuning immune responses. Inflammatory bowel disease (IBD) involves hyperresponsive immunity of the digestive tract, and a low Se level might aggravate IBD progression; however, the beneficial effects of natural Se-enriched diets on IBD remain unknown. Previously, we developed high-yield Se-enriched Spirulina platensis (Se-SP) as an excellent organic nutritional Se source. Here we prepared Se-containing phycocyanin (Se-PC) from Se-SP and observed that Se-PC administration effectively reduced the extent of colitis in mouse induced by dextran sulfate sodium. Supplementation with Se-PC resulted in significant protective effects, including mitigation of body weight loss, bloody diarrhea, and colonic inflammatory damage. The anti-inflammatory effects of Se-PC supplementation were found to involve modulation of cytokines, including IL-6, TNF-α, MCP-1, and IL-10. Mechanistically, Se-PC inhibited the activation of macrophages by suppressing the nuclear translocation of NF-κB, which is involved in the transcription of these pro-inflammatory cytokines. These results together suggest potential benefits of Se-PC as a functional Se supplement to reduce the symptoms of IBD.
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