Significance of second-look ultrasound for breast lesions

Objective: To assess the significance of second-look ultrasound for breast lesions with different diagnosis between enhanced magnetic resonance imaging(MRI) and ultrasound. Materials and Methods: From August 2010 to June 2012,female patients undertaking ultrasound and enhanced MRI were collected successively. For breast lesions with different diagnosis between enhanced MRI and ultrasound, second-look ultrasound(SLUS) was applied. Finally, 14 women were collected, and18 lesions were acquired. The final diagnosis for the breast lesions was based on the pathological diagnosis, so-called golden standard. BI-RADS(Breast imaging reporting and data system) was used in the diagnosis with ultrasound and MRI: lesions of BI-RADS 3, BI-RADS 4a and BI-RADS 4b were considered as benignity. However, lesions of BI-RADS 4c and BI-RADS 5were considered as malignancy. Sensitivity, specificity, accuracy, positive and negative predictive values(PPV and NPV) of second-look ultrasound and enhanced MRI were calculated. The diagnostic rate was tested by Fisher's exact test. When P0.05(double tail), the test was significant. Results: In the 18 lesions confirmed by pathology, 14 lesions were benign and 4 lesions were malignant. The sensitivity, specificity, accuracy, PPV and NPV of second-look ultrasound and enhanced MRI were 75%,92.86%, 88.89%, 75%, 92.86% and 75%, 50%, 55.56%, 30%, 87.5%, respectively. Conclusion: For breast lesions with different diagnosis between enhanced MRI and ultrasound, second-look ultrasound is valuable. The specificity of second-look ultrasound is superior to enhanced MRI.