The study of methylprednisolone in the treatment of septic shock

Objective: The establishment of animal models of septic shock in rabbits, given methylprednisolone (MP) treatment and evaluated its efficacy. Methods: 30 healthy rabbits were randomly divided into methylprednisolone 3 mg/ (kg·d) treatment group, methylprednisolone 1 mg/(kg·d) treatment group,after the shocking, delayed to give methylprednisolone 3 mg/(kg·d) time group and control group, monitored blood pressure in each group pick-up time, cycle time, improving the time and in a stable condition. Results: The recovery time of blood pressure in high-dose methylprednisolone treatment group was shorter than the control group, and the total effective rate were significantly different ( P0.05). Conclusion: In experiment, high-dose methylprednisolone is a safe and effective treatment of septic shock.It may be applied to clinical according to further experiment and clinical study.