生物催化
戒指(化学)
化学
胺气处理
点击化学
立体化学
组合化学
有机化学
反应机理
催化作用
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2018-01-05
卷期号:359 (6371): 44.3-44
标识
DOI:10.1126/science.359.6371.44-c
摘要
Biocatalysis
Most compounds of interest for pharmaceuticals, agrochemicals, and cosmetics have many C–H bonds, interspersed with a few carbon bonds to heavier elements that give them their distinct properties. Chemists therefore prize methods that let them selectively modify a variety of C–H bonds. Gilbert et al. report a versatile strategy that relies on a tethered amine to steer an engineered cytochrome P450 enzyme around 11- or 12-membered rings, transforming specific C–H bonds into C–O bonds. Subtle structural variation of the tether through click chemistry tunes the site selectivity.
ACS Cent. Sci. 10.1021/acscentsci.7b00450 (2017).
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