特发性肺纤维化
TLR9型
纤维细胞
纤维化
医学
肺
病理
任天堂
肌成纤维细胞
癌症研究
免疫学
肺纤维化
生物
内科学
DNA甲基化
生物化学
基因表达
基因
作者
Glenda Trujillo,Alessia Meneghin,Kevin R. Flaherty,Lynette M. Sholl,Jeffrey L. Myers,Ella A. Kazerooni,Barry H. Gross,Sameer R. Oak,Ana Lúcia Coelho,Holly Evanoff,Elizabeth Day,Galen B. Toews,Amrita Joshi,Matthew Schaller,Beatrice Waters,Gábor Járai,John Westwick,Steven L. Kunkel,Fernando J. Martínez,Cory M. Hogaboam
标识
DOI：10.1126/scitranslmed.3001510
摘要
Compared to slow progressors, patients with rapidly progressive idiopathic pulmonary fibrosis express more TLR9, which recognizes unmethylated CpG DNA and stimulates the fibrotic process.
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(2025-6-4)
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