Cumulative C-reactive protein-triglyceride-glucose index and longitudinal trajectories as predictors of new-onset diabetes in middle-aged and older adults: A prospective cohort analysis from CHARLS

Cumulative exposure to CTI and its longitudinal High-Stable trajectories are robust and independent predictors of new-onset diabetes in middle-aged and older adults. Monitoring long-term immuno-metabolic dynamics provides superior risk stratification and significant prognostic implications for personalized diabetes prevention strategies.