多囊卵巢
酪氨酸
内分泌学
色氨酸
内科学
苯丙氨酸
代谢综合征
胰岛素抵抗
亮氨酸
卵泡期
化学
新陈代谢
缬氨酸
氨基酸
生物
肥胖
医学
生物化学
作者
Entai Hou,Yue Zhao,Jing Hang,Jie Qiao
摘要
Abstract Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in women of reproductive age. Some studies have investigated metabolic alterations in plasma and follicular fluid from PCOS patients, but they did not control for obesity or insulin resistance (IR); additionally, correlation analysis of metabolites is sparse. Accordingly, in this study, we aimed to examine metabolic differences owing to the pathogenesis of PCOS, identify the hub metabolites and investigate its associations with androgens. We applied GC–MS platform coupled with a correlation network approach to analyze follicular fluid samples from 32 PCOS patients without obesity and IR and 31 healthy women. Thirty significantly altered metabolites in PCOS patients were enriched in amino acid metabolism. l ‐Phenylalanine, l ‐tryptophan, pyroglutamic acid, l ‐tyrosine, l ‐leucine and l ‐valine were screened as hub metabolites in metabolic correlation network. Among them, increased l ‐tryptophan and l ‐tyrosine were altered hub metabolites, and they had a more significant impact on the metabolic change of PCOS. In addition, l ‐tryptophan and l ‐tyrosine were significantly positively associated with serum androgens levels in the PCOS. Our results suggest that disorders of amino acid metabolism, especially tryptophan and tyrosine metabolism, might play an important role in the development of PCOS in predisposed women without obesity and IR.
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