化学
喹啉
烷基化
酰化
试剂
药物化学
反应性(心理学)
噻吩
腈
有机化学
水杨醛
立体化学
催化作用
替代医学
病理
席夫碱
医学
作者
Ameen A. Abu‐Hashem,Ahmed A. M. Abdelgawad,Hoda A. R. Hussein,Moustafa A. Gouda
出处
期刊:Mini-reviews in Organic Chemistry
[Bentham Science]
日期:2022-02-01
卷期号:19 (1): 74-91
被引量:11
标识
DOI:10.2174/1570193x18666210218212719
摘要
Abstract: This review describes the synthesis and chemical reactivity of tetrahydrothieno[3,2-b] quinoline derivatives from through many of the reagents such as; 1, 2-dihydropyridine-3-carbonitrile; 1,6-dihydropyrimidine-5-carbonitrile; 2,3-dihydropyridazine-4-carbonitrile; 3-amino-thiophene-2-carboxylate; 3-amino-thiophene-2-carbonitrile; 3,4-diaminothieno[2,3-b] thiophene-2,5-dicarbo- nitrile; 2-(3-bromo-1-iodoisoquinolin-8-yl) benzonitrile and 3-mercapto-benzo[g]quinolin-4(1H)-one derivatives. The synthesis of the tetrahydrothieno [3, 2-b] quinoline derivatives were explained through the following chemical reactions: Aldol condensation, alkylation, cyclocondensation, dehydration, chlorination, Wolff-Kishner reduction, acylation, Friedlander reaction and intramolecular cyclization.
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