Microneedles loaded with anti-PD-1–cisplatin nanoparticles for synergistic cancer immuno-chemotherapy

The synergistic effects of immuno-chemotherapy delivered through a microneedle. aPD-1 blocks the binding of PD-L1 to PD-1, leading to the activation of T-cells. Intracellular release of CDDP induces direct cytotoxicity to the tumor cells.