糖基化
糖复合物
聚糖
炎症
细胞生物学
糖基转移酶
细胞
生物
细胞粘附
糖生物学
生物化学
化学
糖蛋白
免疫学
酶
作者
Sophie Groux-Degroote,Sumeyye Cavdarli,Kenji Uchimura,Fabrice Allain,Philippe Delannoy
出处
期刊:Advances in protein chemistry and structural biology
日期:2020-01-01
卷期号:: 111-156
被引量:29
标识
DOI:10.1016/bs.apcsb.2019.08.008
摘要
Glycosylation is one of the most important modifications of proteins and lipids, and cell surface glycoconjugates are thought to play important roles in a variety of biological functions including cell-cell and cell-substrate interactions, bacterial adhesion, cell immunogenicity and cell signaling. Alterations of glycosylation are observed in a number of inflammatory diseases. Pro-inflammatory cytokines have been shown to modulate cell surface glycosylation by regulating the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of glycan chains, inducing the expression of specific carbohydrate antigens at the cell surface that can be recognized by different types of lectins or by bacterial adhesins, contributing to the development of diseases. Glycosylation can also regulate biological functions of immune cells by recruiting leukocytes to inflammation sites with pro- or anti-inflammatory effects. Cell surface proteoglycans provide a large panel of binding sites for many mediators of inflammation, and regulate their bio-availability and functions. In this review, we summarize the current knowledge of the glycosylation changes occurring in mucin type O-linked glycans, glycosaminoglycans, as well as in glycosphingolipids, with a particular focus on cystic fibrosis and neurodegenerative diseases, and their consequences on cell interactions and disease progression.
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