Study on transdermal drug delivery with microneedle array

Abstract New pathways of drug administration have being explored because there exist weaknesses in the traditional drug delivery such as either potential degradation in the gut in oral method or pain and infection resulted from transdermal injection. Transdermal drug delivery (TDD) is a promising technology for drug administration. Among TDD, Microneedles (MNs) made transdermal drug delivery easier and more effective. The development of microneedles is necessary to eliminate or reduce the problems employing conventional needles such as pain, needle-stick injuries or needle re-use. In order to explore the drug delivery in human tissues, we made the hypothetical models of the flow of drug and to depict the flow and the moving ways of drugs. The delivering properties of drugs into skin tissue are analysed by adopting the previous hypothetical models. The results showed that the exiting velocity from the microneedle array played an important role to impact the efficiency of drug delivery. The large exiting velocity would accelerate the transdermal drug delivery and prompt drug into the circulation. In addition, the diffusion can be ignored due to a little influence.