Admission glucose is a significant outcome predictor in anterior circulation stroke: approaching the sweet spot

BACKGROUND: Admission glycemia has emerged as an important outcome predictor in the context of mechanical thrombectomy (MT) for large vessel occlusions (LVO) in ischemic stroke. However, a clinically relevant threshold of glucose levels to identify patients at risk for poor functional outcome has yet to be established. METHODS: We conducted a retrospective, monocentric, consecutive registry-based analysis of patients who underwent MT for anterior circulation LVO. Good outcome was defined as functional independence after 90 days (90d mRS < 3) or no deterioration from premorbid mRS. We performed a multiple logistic regression analysis to assess the association between admission glucose levels and functional outcome, including for well-established outcome predictors, i.e. age, NIHSS, Alberta Stroke Program Early CT Score (ASPECTS), time to reperfusion, unsuccessful recanalization, presence of bleeding, and diabetes. In addition, we conducted a receiver operating characteristic (ROC) analysis to determine the optimal admission glucose threshold that best discriminates patients at risk for poor outcome, maximizing sensitivity and specificity. RESULTS: We analyzed 509 patients (mean age = 74.3 ± 12.6 years, median previous mRS = 1.5, 48% male). 194 patients (38.1%) had good outcome and 315 (61.9%) had poor outcome. According to the logistic regression admission glucose (p = 0.012, OR 1.009 95% CI [1.002 1.016]) contributed to predicting poor outcome, while known diabetes did not show a significant contribution. The ROC analysis revealed an admission glucose of 117 mg/dL (59.7% sensitivity; 58% specificity) to be the optimal cut-off value to discriminate patients at risk for poor outcome with an OR of 2.3. CONCLUSION: Admission hyperglycemia is an independent predictor of poor outcome after MT for LVO in the anterior circulation. We hypothesize, that optimal glucose values in patients undergoing MT will likely be in the low normoglycemic range. Prospective controlled studies with targeted glucose values will be needed for validation.