Recent Progress on the Rational Design of Laccase Mimics

Laccase, a type of copper-containing natural oxidase, is known as a green catalyst because only water was produced as the reduction product. It has shown great potential for applications in wastewater treatment, dye degradation, food and pharmaceutical industries, biosensors, and other fields. Despite the above advantages of natural laccase, challenges arise from its inherent instability, recovery difficulties, and the associated high costs exist. To address such issues, a plethora of nanomaterials that possess laccase-mimicking activity, ranging from monometallic ions-containing nanomaterials to multimetal-based composites, was discovered in the past decade. In general, these materials demonstrate considerable performance variability. A comprehensive understanding of the design principles to achieve high laccase-like activity, particularly those on the Cu²⁺-involved structures and the related electron transfer, is thus demanded. Therefore, in this review, the structure-activity relationship of native laccase was first summarized, followed by the categorization of the recent design strategies of laccase-like nanozymes. After distilling the insights from the currently reported laccase-mimicking nanomaterials, a further prospect on the rational design of laccase mimics with high efficiency in the future was also proposed.