生物
细菌外膜
赖氨酸
障碍物
微生物学
遗传学
大肠杆菌
噬菌体
政治学
法学
基因
作者
Hazel M. Sisson,Simon A. Jackson,Robert D. Fagerlund,Suzanne L. Warring,Peter C. Fineran
标识
DOI:10.1016/j.mib.2024.102433
摘要
Our ability to control the growth of Gram-negative bacterial pathogens is challenged by rising antimicrobial resistance and requires new approaches. Endolysins are phage-derived enzymes that degrade peptidoglycan and therefore offer potential as antimicrobial agents. However, the outer membrane (OM) of Gram-negative bacteria impedes the access of externally applied endolysins to peptidoglycan. This review highlights recent advances in the discovery and characterization of natural endolysins that can breach the OM, as well as chemical and engineering approaches that increase antimicrobial efficacy of endolysins against Gram-negative pathogens.
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