恶唑啉
化学
抗真菌
组合化学
催化作用
微波辐射
有机化学
分子内力
皮肤病科
医学
作者
Cynthia Nathalia Pereira,Amanda Cristina Cruz Eschholz,Maurício Silva dos Santos
出处
期刊:Current Organic Synthesis
[Bentham Science]
日期:2024-01-12
卷期号:21
标识
DOI:10.2174/0115701794283180231228075225
摘要
Abstract: Oxazolines are important heterocyclic systems due to their biological activities, such as antibacterial, antimalarial, anticancer, antiviral, anti-inflammatory, antifungal, antipyretic, and antileishmanial. They have been widely applied as chiral auxiliaries, polymers, catalysts, protecting groups, building blocks, and ligands in asymmetric synthesis. Due to their importance, many synthetic routes to prepare oxazoline moieties have been investigated and developed by researchers around the world. In this review, we summarized several synthetic methodologies published in the literature. The main substrates are nitriles, carboxylic acids, and acid derivatives, which react with a variety of reactants under conventional heating, microwave irradiation or ultrasound irradiation conditions. Syntheses via intramolecular cyclisation from amides have also been reported. Many publications have highlighted procedures based on solvent-free conditions using eco-friendly, reusable, and easy-availability catalysts.
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