Research Progress on Construction of Heterocyclic Skeletons Based on α-Hydride Transfer Strategy

The efficient construction of heterocyclic compounds is an important topic in the field of organic synthesis.[m＋n] cyclization reaction can form privilege molecules from the combination of two readily available reaction substrates, which is an important means for construction of cyclic skeletons.The [m＋n] cyclization reaction based on hydride transfer strategy can in situ generate hydride acceptor from two relatively simple substrates, avoiding the prefabrication of reaction substrates, which features high atom and step economy.In this review, the [m＋n] cyclization reactions based on hydride transfer strategy are selected as the research object.Starting from the framework of aza-and oxa-heterocycles constructed by this kind of reaction, this review is classified according to the size of the generated aza-and oxa-heterocycles.The recent progress of [m＋n] cyclization based on hydride transfer strategy since 2018 is summarized, and the development of this field is also prospected.Keywords heterocyclic compounds; hydride