Comparative Study of Collagen Granules Dressing Versus Conventional Dressing in Wound Healing

Introduction: Collagen, a proline -rich protein, is crucial in wound healing due to its role in debridement, angiogenesis and re -epithelialization. This study compares the effectiveness of collagen granule dressing versus conventional dressing in wound healing. the prospective cohort study involved 68 patients divided into test and control groups. results showed a significant decrease in healing time for the collagen group, with faster granulation and reduced need for skin grafting. collagen dressing demonstrated nonimmunogenic, being natural, easy application benefits making it superior to conventional methods. Aim: this study main objective to compare the effectiveness of collagen granule dressing versus conventional dressing in the healing of deep wounds, focussing on healing time, granulation tissue formation, and the need for skin grafting. Methods: This is a prospective cohort study. After obtaining ethical clearance from Institute's ethical committee, all the patients fulfilling inclusion criteria were enrolled, and written consent was obtained from all the patients. Detailed history was enquired and recorded on a predesigned proforma. The wound healing, analysed as -Time required for appearance of healthy granulation tissue, 50% reduction in wound size, complete healing time, requirement of skin grafting, time required in return to daily activities. Results: A significant decrease in time required for 50 % reduction in wound size with a mean difference of 18.5 in collagen group patients when compared to 37.5 in Normal saline group patients. Chi square test was applied to assess the difference in proportions between groups t test was applied to compare the mean between the groups. P<0.05 was considered as statistically significant. Conclusions: Healing with collagen particles is early, compared to the conventional dressings with lesser requirement of skin grafting, number of dressings, shorter hospital stay. Dressing changed every 3 -4 days. Healing occurs by formation of early granulation tissue and wound contraction.