An azoreductase activatable, endonuclease-gated nanodevice for spatiotemporal amplification imaging of microRNA-21 in hypoxic tumor cells

Herein, we report an azoreductase activatable, endonuclease-gated fluorescent nanodevice for spatiotemporal amplification imaging of microRNA-21 in hypoxic tumor cells. We hope that this work can provide a new tool for accurate monitoring of the abundance of intracellular biomolecules and diagnosis of diseases in the future.