腺癌
微泡
生物标志物
肿瘤科
肺癌
阶段(地层学)
外体
肺
小RNA
内科学
癌症研究
癌症
医学
化学
生物
基因
古生物学
生物化学
作者
Wenting Fang,Jianbin You,Qifeng Xu,Yihui Jiang,Hongxiang Hu,Falin Chen,Liangyuan Chen
出处
期刊:Clinical Laboratory
[Clinical Laboratory Publications]
日期:2022-01-01
卷期号:68 (10/2022)
被引量:1
标识
DOI:10.7754/clin.lab.2022.220128
摘要
Lung cancer is a leading cause of cancer-related death, with lung adenocarcinoma (LUAD) representing the most common subtype. Recently, exosome-based biomarkers have provided new diagnostic approaches for malignancies.The differential expression profile of plasma exosomal mRNA was established by high-throughput sequencing, and the expression and diagnostic value of plasma exosomal CXCL7 mRNA and protein in LUAD were studied to evaluate their diagnostic value as tumor biomarkers.The expression of plasma exosomal CXCL7 mRNA in patients with LUAD was significantly increased (p < 0.01), which had no significant correlation with age, gender, and stage. ROC was used to evaluate the diagnostic value of plasma exosomal CXCL7 mRNA in LUAD patients with AUC = 0.7171. Further analysis signified that the CXCL7 protein of plasma exosomes in LUAD patients was overexpressed, and it was positively correlated with TNM stage and age. The diagnostic value of plasma exosomal CXCL7 in LUAD is better than serum CEA, with an AUC of 0.785, which has higher sensitivity and specificity.This research suggests that plasma exosomal CXCL7 may become an effective biomarker for early diagnosis of LUAD.
科研通智能强力驱动
Strongly Powered by AbleSci AI