化学
叠氮化物
重氮甲烷
叠氮三甲基硅
锗
胺气处理
催化作用
铜
区域选择性
锗化合物
有机化学
药物化学
硅
作者
Yani Luo,Leiyang Lv,Zhiping Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-10-25
卷期号:24 (43): 8052-8056
被引量:13
标识
DOI:10.1021/acs.orglett.2c03302
摘要
The incorporation of a germyl group and another functional fragment across the C═C bond is a challenging task due to the prevailing hydrogermylation reaction. Herein, an efficient copper-catalyzed three-component reaction of alkenes, germanium hydrides, and trimethylsilyl azide has been disclosed. This transformation allows the concomitant introduction of germyl and azide groups across the double bonds in a highly regioselective manner with tert-butyl hydroperoxides as the bystanding oxidant. The resulting β-germyl azides could be easily converted into β-germyl amine and 1,2,3-triazoles of significant value.
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