胰腺癌
恶性肿瘤
医学
胰腺导管腺癌
癌症
人口
癌症筛查
重症监护医学
肿瘤科
内科学
环境卫生
作者
Jérôme Schwingel,Miriam Decker,Lisa Schneider,Carsten Johannes Stürmer,Manfred P. Lutz
出处
期刊:Oncology Research and Treatment
[S. Karger AG]
日期:2023-01-01
卷期号:46 (6): 259-267
摘要
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that is increasingly common. Screening for pancreatic cancer is not well established but might increase the chance of detection in early stages. Summary: We conducted a literature search to summarize current recommendations and to give an overview of patient groups that may benefit from screening. In the general population, screening is not recommended because the low prevalence of PDAC renders any diagnostic tests non-predictive and because there is no direct evidence that links early diagnosis to improved survival. To date, novel approaches like liquid biopsies and molecular markers are not yet able to improve screening in unselected individuals but offer promising potential. Screening efficiency increases considerably with increasing pretest probability. Therefore, the best way to improve early diagnosis is identifying high-risk individuals. Key Messages: There are well-defined populations with distinct genetic alterations with an increased risk for pancreatic cancer. Those may be screened with common diagnostic methods. In addition, new-onset diabetes is increasingly recognized as an early symptom, especially in elderly patients with weight loss.
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