Leveraging Medical Knowledge Graphs Into Large Language Models for Diagnosis Prediction: Design and Application Study

DR.KNOWS offers a robust approach for enhancing diagnostic accuracy and reasoning by integrating structured KG knowledge into LLM-based clinical workflows. Although further work is required to address KG biases and extend generalizability, DR.KNOWS represents progress toward trustworthy artificial intelligence-driven clinical decision support, with a human evaluation framework focused on diagnostic safety and alignment with clinical standards.