Acrolein-triggered atherosclerosis <i>via</i> AMPK/SIRT1-CLOCK/BMAL1 pathway and a protection from intermittent fasting

Circadian clock plays a vital role in the pathological progression of cardiovascular disease (CVD). Our previous studies showed that acrolein, an environmental pollutant, promoted atherosclerosis by reducing CLOCK/BMAL1 and disturbing circadian rhythm. Whereas, intermittent fasting (IF), a diet pattern, was able to ameliorate acrolein-induced atherosclerosis.