The Synthesis of Amide and its Bioisosteres

Amide bonds represent crucial functional groups in numerous biomolecules and pharmaceuticals,characterized by distinct structures and properties, and are essential for drug synthesis.By employing a bioisosteric replacement strategy, innovative drug architectures can be devised thatcircumvent existing patent protections, thereby offering an effective avenue for the discovery ofnew drug candidates. This review primarily introduces the current synthetic methodologies for amidesand their bioisosteres. Additionally, it discusses the advantages and disadvantages associatedwith various functional groups. A comparative analysis of the differing properties of amides andtheir bioisosteres within compounds is also presented.