This study investigates slope stability in an open-pit mining area by integrating engineering geological surveys, field investigations, and laboratory rock mechanics tests. A coordinated multimethod analysis was carried out using finite element-based numerical simulations from both two-dimensional and three-dimensional perspectives. The integrated approach revealed deformation patterns across the slopes and established a multiscale analytical framework. The results indicate that the slope failure modes primarily include circular and compound types, with existing step slopes showing a potential risk of wedge failure. While the designed slope meets safety requirements under three working conditions overall, the strongly weathered layer in profile XL3 requires a slope angle reduction from 38° to 37° to comply with standards. Three-dimensional simulations identify the main deformations in the middle-lower sections of the western area and zones B and C, with faults located at the core of the deformation zone. Rainfall and blasting vibrations significantly increase surface tensile stress, accelerating deformation. Although wedges in profiles XL1 and XL4 remain generally stable, coupled blasting–rainfall effects may still induce potential collapse in fractured areas, necessitating preventive measures such as concrete support and bolt support, along with real-time monitoring to dynamically optimize reinforcement strategies for precise risk control.