免疫疗法
医学
免疫系统
癌症免疫疗法
癌症
发病机制
免疫学
免疫检查点
癌症研究
生物信息学
计算生物学
作者
Jin Tian,Yuanyuan Liu,TengLong Zhang,Lu Yue,YaNan Xiao,ChengYe Guo
标识
DOI:10.1080/14737140.2022.2039124
摘要
Lymphocyte activation gene-3 (LAG-3) is a member of the immunoglobulin superfamily. Engagement of LAG-3 by its ligands to trigger downstream signaling can inhibit immune responses and regulate the pathogenesis of many diseases, including cancer and inflammatory diseases.We used keywords to search for relevant publications in PubMed and information on websites. After systematic analysis, we discuss the biological characteristics of LAG-3 and its ligands, LAG-3 related signaling, its roles in the pathogenesis of tumors, and its blockages for the treatment of cancers, as well as current challenges and future directions of research.Although the mechanisms underlying the action of LAG-3/ligand-related signaling in tumor development are not fully understood, advances in scientific research and LAG-3-based immunotherapies are promising. Further studies to explore its biological roles and molecular mechanisms may aid in developing new LAG-3- and ligand-based therapeutic drugs to benefit patients with different types of cancers.
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