结合
Zeta电位
拉曼光谱
共轭体系
傅里叶变换红外光谱
核化学
荧光
药物输送
MTT法
材料科学
碳纤维
荧光光谱法
透射电子显微镜
化学
分析化学(期刊)
纳米颗粒
纳米技术
化学工程
色谱法
体外
生物化学
有机化学
复合数
聚合物
工程类
数学
光学
数学分析
物理
量子力学
复合材料
作者
P. Chandrasekaran,Gandhi Sivaraman,Swetha Rasala,Mathur Gopalakrishnan Sethuraman,Niranjan G. Kotla,Yury Rochev
出处
期刊:Soft Matter
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:18 (30): 5645-5653
被引量:15
摘要
In this work, we report the development of nitrogen-doped carbon dots (NDCDs) as a drug carrier using quercetin (QC) as a model drug for anti-cancer drug delivery application. NDCDs were prepared by a simple hydrothermal method using Luffa acutangula as a carbon source. The characterization of QC-NDCDs was done by UV-vis spectroscopy, fluorescence spectroscopy, zeta potential measurements, high-resolution transmission electron microscopy (HR-TEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and Raman spectroscopy. The as-synthesized NDCDs have a small particle size with hydroxyl and nitrogen-containing groups (pyridinic and amide groups), enhancing the fluorescence properties, and were obtained in a good quantum yield (14%). Furthermore, the in vitro alamarBlue® assay revealed that the NDCDs-QC conjugate was nontoxic to colon cancer cells. This NDCDs-QC conjugate is able to kill cancer cells in the NDCDs-QC form compared to free QC as confirmed by in vitro MTT assay results. Thus, the developed NDCDs conjugate can be used as a promising drug delivery and bio-imaging vehicle in cancer therapy.
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