药物输送
生物利用度
批准的药物
纳米技术
药理学
药品
医学
风险分析(工程)
材料科学
作者
Pedro Sebastián Londoño Ruiz,Mairim Russo Serafini,Izabel Almeida Alves,Diana Marcela Aragón Novoa
出处
期刊:Critical Reviews in Therapeutic Drug Carrier Systems
[Begell House Inc.]
日期:2022-01-01
卷期号:39 (2): 1-77
被引量:5
标识
DOI:10.1615/critrevtherdrugcarriersyst.2021038490
摘要
Self-emulsifying drug delivery systems (SEDDS) are lipid-based isotropic mixtures that enhance the bioavailability of poorly water-soluble drugs and reduce the possible side effects, offering a wide variety of treatments for several pathologies. The aim of this review is to discuss the state of the art of patents for this drug delivery system by studying recent patent applications (2011 to 2020). We performed a thorough screening using the European Patent Office's Espacenet database, from which 37 inventions were selected and fully studied. China had more patent applications, and the articles published about SEDDS exceeds both in number and technological advance the submitted inventions. Nevertheless, the patents presented herein are innovative to address known issues to traditional SEDDS, including storage and formulation stability, solid formulations, acute gastrointestinal toxicity from surfactants, and drug delivery through alternative routes of administration. This study also revealed that release behavior for SEDDS and associated pharmacokinetics were not completely disclosed by the inventors of the patents and that further studies are required.
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