荧光团
光热治疗
单线态氧
紧身衣
光漂白
光动力疗法
材料科学
小泡
光化学
荧光
生物物理学
纳米技术
化学
膜
氧气
光学
有机化学
生物
物理
生物化学
作者
Hongchao He,Shuangshuang Ji,Yang He,Aijun Zhu,Yelin Zou,Yibin Deng,Hengte Ke,Hong Yang,Youliang Zhao,Zhengqing Guo,Huabing Chen
标识
DOI:10.1002/adma.201606690
摘要
Photoconversion tunability of fluorophore dye is of great interest in cancer nanomedicine such as fluorescence imaging, photodynamic therapy (PDT), and photothermal therapy (PTT). Herein, this paper reports wavelength-dependent photoconversional polymeric vesicles of boron dipyrromethene (Bodipy) fluorophore for either PDT under 660 nm irradiation or PTT under 785 nm irradiation. After being assembled within polymeric vesicles at a high drug loading, Bodipy molecules aggregate in the conformations of both J-type and H-type, thereby causing red-shifted absorption into near-infrared region, ultralow radiative transition, and ideal resistance to photobleaching. Such vesicles further possess enhanced blood circulation, preferable tumor accumulation, as well as superior cell uptake as compared to free Bodipy. In particular, the vesicles mainly generate abundant intracellular singlet oxygen for PDT treatment under 660 nm irradiation, while they primarily produce a potent hyperthermia for PTT with tumor ablation through singlet oxygen-synergized photothermal necrosis under 785 nm irradiation. This approach provides a facile and general strategy to tune photoconversion characteristics of fluorophore dyes for wavelength-dependent photoinduced cancer therapy.
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